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With Pluto in the 12th house, you have a deep interest in secrets, the unconscious, and anything mysterious. This would include psychoanalysis, investigating dreams and other methods of uncovering the hidden caverns of the mind and universe, which are all maddeningly fascinating to you. Such activities tap into your exceptionally perceptive, intuitive, and psychic inner being. The depths of your subconscious are explored, and there may be a powerful urge to study the invisible side of life or another avenue that allows you to dig into the unconscious realms of the human psyche. In addition, since you possess a powerful psychic sensitivity to the hidden lives of others, this placement, according to Sue Tompkins, is like a psychic refuse bin, and you absorb the negativity around you; all the unexpressed grief and fears that others conceal behind a happy face.  It helps that you have such a powerful reservoir of healing power, regenerative ability, capability and strength in the face of unimaginable terror. However, this also means that you go through sustained periods of inner growth and periodic transformations and perhaps a severe inner crisis is experienced.

Common characteristics of Pluto in the twelfth house include: being deeply private, not what they seem as interpreted in other’s eyes, deeply sensitive; taking things to heart; being amazingly shy at a core level; being ultra-emotional; although you may not know it, they can be extremely giving in a silent way; having many deep and unresolved fears, and aura of dreaminess, and powerful dreams or never any dreams because of exhaustion; being naturally psychic. Pluto: The Evolutionary Journey of the Soul, Volume 1

When Pluto is in the 12th house, there is unfathomable and complex emotional guilt and feelings of persecution, and it is not unlikely for you to take on the role of the scapegoat. Commonly there is a dark history of abuse, brutality, or violence, and a sense that there is something shadowy lurking in the background. Being born with this placement presents you with the challenge of not feeling overwhelmed by the collective shadow of suffering, sadness, and grief. This transforming planet is working to change this shadowy element in your life, but it always involves bringing those repressed parts that are weak and undeveloped into full awareness so that they are faced and integrated into your personality.

This is a frequent placement in the charts of those who work in mental health, crisis situations, counseling, and crime prevention. It comes about because there is a deep need to do something for humanity that will benefit others. Problematic areas relating to this realm are unseen health problems, addictions, excessive escapism, and an overwhelming feeling of powerlessness. It can, therefore, symbolize an obsessive survival instinct operating below the surface of consciousness, and way back in the psyche of your family. Stephen Arroyo: Astrology Karma and Transformation, points out that this house reveals influences beyond your conscious control released only through therapy, self-analysis, and soul-work.